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Wickerols A and B: novel anti-influenza virus diterpenes produced by Trichoderma atroviride FKI-3849
Tsuyoshi YamamotoNaoyuki Izumi Hideaki Ui Akito SuekiRokuro Masuma Kenichi NonakaTomoyasu Hirose Toshiaki Sunazuka Takayuki Nagai Haruki Yamada Satoshi ōmura Kazuro Shiomi 《Tetrahedron》2012,68(45):9267-9271
Wickerols A and B were produced by a fungus, Trichoderma atroviride FKI-3849. Wickerol A showed potent anti-influenza virus activity against strain A/PR/8/34 (H1N1), whereas wickerol B exhibited weaker impact. The anti-influenza virus spectrum between wickerols A and B was different. The cyclization mechanism of the wickerol carbon-skeleton was investigated by incorporation of 13C-labeled acetate. A pathway through the verticillyl cation was predicted. 相似文献